Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis
نویسندگان
چکیده
منابع مشابه
Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis.
Genome-wide association studies have identified a link between genetic variation at the human chromosomal locus 1p13.3 and coronary artery disease. The gene encoding sortilin (SORT1) has been implicated as the causative gene within the locus, as sortilin regulates hepatic lipoprotein metabolism. Here we demonstrated that sortilin also directly affects atherogenesis, independent of its regulator...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2014
ISSN: 0021-9738
DOI: 10.1172/jci76002